function difference(arr1,arr2) {  
 var a1= flatten(arr1,true);  
 var a2= flatten(arr2,true);  
 var a=[], diff=[];  
  for(var i=0;i<a1.length;i++)  
  a[a1[i]]=false;  
  for(i=0;i<a2.length;i++)  
  if(a[a2[i]]===false)   
  { delete a[a2[i]];}  
  else a[a2[i]]=true;  
  for(var k in a)  
  diff.push(k);  
  return diff;   
  }  
  var flatten = function(a, shallow,r){  
  if(!r){ r = [];}  
  if (shallow) {  
  return r.concat.apply(r,a);  
  }   
  for(i=0; i<a.length; i++){  
  if(a[i].constructor == Array){  
  flatten(a[i],shallow,r);  
  }else{  
  r.push(a[i]);  
  }  
  }  
  return r;  
  };  
  console.log(difference([1, 2, 3], [100, 2, 1, 10]));  
  console.log(difference([1, 2, 3, 4, 5], [1, [2], [3, [[4]]],[5,6]]));  
  console.log(difference([1, 2, 3], [100, 2, 1, 10]));